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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SETD1B
All Species:
5.15
Human Site:
T1195
Identified Species:
8.72
UniProt:
Q9UPS6
Number Species:
13
Phosphosite Substitution
Charge Score:
-0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9UPS6
NP_055863.1
1923
208732
T1195
E
E
E
V
D
I
E
T
E
A
V
A
P
E
E
Chimpanzee
Pan troglodytes
XP_523492
1707
185692
S1052
S
S
S
S
S
S
S
S
S
S
S
S
S
S
E
Rhesus Macaque
Macaca mulatta
XP_001092031
624
66545
Dog
Lupus familis
XP_543382
1925
209302
A1199
E
E
E
V
D
I
E
A
E
D
E
A
P
E
E
Cat
Felis silvestris
Mouse
Mus musculus
Q8CFT2
1985
215333
A1256
E
E
E
V
D
I
E
A
E
D
E
V
P
E
M
Rat
Rattus norvegicus
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001510235
695
75024
L57
Q
R
S
R
L
L
L
L
L
L
H
D
N
P
G
Chicken
Gallus gallus
Q5F3P8
2008
223067
P1264
E
P
E
V
Q
E
C
P
K
P
E
S
Q
D
E
Frog
Xenopus laevis
Q66J90
1938
216239
T1149
E
Q
D
V
A
H
Q
T
A
Q
D
T
S
H
L
Zebra Danio
Brachydanio rerio
Q1LY77
1844
204122
L1106
P
E
E
E
P
N
E
L
G
R
L
E
A
V
D
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_001015221
1641
188364
T1002
T
D
E
D
N
D
R
T
L
F
P
A
L
K
E
Honey Bee
Apis mellifera
XP_395451
1406
159180
Q768
S
G
N
F
E
D
E
Q
D
T
D
S
H
L
S
Nematode Worm
Caenorhab. elegans
Q18221
1507
171664
A869
E
H
H
H
H
A
K
A
S
V
S
T
P
V
H
Sea Urchin
Strong. purpuratus
XP_791552
1963
220543
F1136
P
F
S
M
P
P
G
F
P
S
A
S
A
P
P
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Q8X0S9
1313
145607
R675
V
F
D
D
S
E
G
R
S
S
P
V
G
T
P
Conservation
Percent
Protein Identity:
100
37.3
27.9
91.9
N.A.
87.7
N.A.
N.A.
23.1
61.5
55
51
N.A.
24.7
23.9
22.3
21.3
Protein Similarity:
100
50.3
28.8
93.9
N.A.
90.2
N.A.
N.A.
26.7
71.1
66.6
63.6
N.A.
39.4
38.6
35.2
35.2
P-Site Identity:
100
6.6
0
80
N.A.
66.6
N.A.
N.A.
0
26.6
20
20
N.A.
26.6
6.6
13.3
0
P-Site Similarity:
100
26.6
0
80
N.A.
66.6
N.A.
N.A.
13.3
46.6
40
33.3
N.A.
46.6
26.6
20
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
22.2
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
35.4
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
0
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
13.3
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
8
8
0
22
8
8
8
22
15
0
0
% A
% Cys:
0
0
0
0
0
0
8
0
0
0
0
0
0
0
0
% C
% Asp:
0
8
15
15
22
15
0
0
8
15
15
8
0
8
8
% D
% Glu:
43
29
43
8
8
15
36
0
22
0
22
8
0
22
36
% E
% Phe:
0
15
0
8
0
0
0
8
0
8
0
0
0
0
0
% F
% Gly:
0
8
0
0
0
0
15
0
8
0
0
0
8
0
8
% G
% His:
0
8
8
8
8
8
0
0
0
0
8
0
8
8
8
% H
% Ile:
0
0
0
0
0
22
0
0
0
0
0
0
0
0
0
% I
% Lys:
0
0
0
0
0
0
8
0
8
0
0
0
0
8
0
% K
% Leu:
0
0
0
0
8
8
8
15
15
8
8
0
8
8
8
% L
% Met:
0
0
0
8
0
0
0
0
0
0
0
0
0
0
8
% M
% Asn:
0
0
8
0
8
8
0
0
0
0
0
0
8
0
0
% N
% Pro:
15
8
0
0
15
8
0
8
8
8
15
0
29
15
15
% P
% Gln:
8
8
0
0
8
0
8
8
0
8
0
0
8
0
0
% Q
% Arg:
0
8
0
8
0
0
8
8
0
8
0
0
0
0
0
% R
% Ser:
15
8
22
8
15
8
8
8
22
22
15
29
15
8
8
% S
% Thr:
8
0
0
0
0
0
0
22
0
8
0
15
0
8
0
% T
% Val:
8
0
0
36
0
0
0
0
0
8
8
15
0
15
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _